Response to major opener.
When using Inverted Trump Swiss a way to splinter is needed. Ambiguous Splinters work well here.
Also when using Inverted Swiss you can now use Jacoby 2NT for 16+
There are many ways to play these 4 level jumps. You could reverse the meanings of 4 and 4 or have them mean something slightly for example showing or denying 1 of the top 3 honors or promising number of keycards instead.